Both new flights will be operated daily on a seasonal basis, from May to September for the summer travel season.
American will serve the route from DFW to Amsterdam Airport Schiphol with Boeing 767-300 aircraft.
"One of our top goals at DFW Airport is to grow international passenger and cargo air service in order to spur new business and travel opportunities in our home region, and the addition of these new flights will certainly help connect the Dallas Fort Worth area to more of Europe," said Sean Donohue, chief executive officer at DFW Airport.
"We are excited to offer these new seasonal routes from our largest hub, connecting North Texas to popular leisure destinations in Europe," said Vasu Raja, American's vice president – Network and Schedule Planning.
When the flight begins in May, DFW customers will enjoy nonstop service to Rome for the first time ever, and that flight connects DFW to its largest unserved international market.
"We are also looking forward to welcoming customers arriving from Rome and Amsterdam with our renowned Texas hospitality, whether they are visiting the Dallas Fort Worth area or connecting to another destination," said Donohue.
"Our new additions to International Terminal D including the new duty free retail complex will let visitors know they are in for a world-class customer experience at our Airport."